From Kawasaki Disease to Candida

Kawasaki Disease


In 1981 at the age of seven, I had acute Kawasaki Disease (KD).  Twenty-seven years later, I found myself desperate enough to try naturopathic remedies due to a decade of severe GI problems among many other minor things.  It seems to me that Candida has slowly proliferated throughout my body causing various minor health issues that are not easy to diagnose.  I have positively affected many minor issues including severe migraines that began immediately post-KD.  I had never even given KD a thought until I started affecting things I associated with KD all of these years later.  The role of Candida in the degeneration of health and the actions I have taken are originally documented in a book called The Yeast Connection by Dr. William Crooks, it is not medically accepted and yet it has created an industry with a disturbing number of followers.  Even more disturbing are the older post-KD people on the KD Discussion Forum that tell of many of the same symptoms as me (and The Yeast Connection), the existence of sequels (i.e. recurrence of KD/aneurysms) even decades later and a great deal of data indicating that this disease is not restricted to the children it has primarily been associated with but that it affects them to a much greater extent.

Given my history and the strength of the
Herxheimer or die-off reactions from treatment, I have asked myself what this means and performed a great deal of research along this line of thought.

I believe that acute KD is when an undiagnosed infection of something commonly found in the body, but allowed to grow to substantial quantity, is exposed to another pathogen or chemical that rapidly kills it off and causes a huge
Herxheimer reaction and that incomplete KD is a result of the proliferation and (lesser) toxic release of this infection coordinated through quorum sensing.  I  suspect that Candida, the pathogen that causes diaper rash, yeast infections and skin/nail infections to be a common pathogen that proliferates freely under the genetic conditions already noted in KD.  I have researched many medical experiments relating the properties of KD to those observed in Candida (superantegenic properties, IL-2, TNF alpha, vbeta, etc) in order to disprove my thoughts and found no definitive refutations (though I am not a doctor or naturopath).  There are medical experiments around theKiller-Sensitivecharacteristics of Candida proving that it can be decimated by toxins it is sensitive to.  Models of vaculitis/arteritis (i.e. inflammation) studied within KD use a base level infection, of which Candida is one.  There are many relationships along this line of thought including the role of the BCG (TB) vaccine, role of immunoglobulin and the entwinement of many other pathogens as something a base infection of self reacts to OR as base infections of self.  

It has already been noted that there are a great many pathogens involved in KD, that acute KD portrays as sepsis and that the superantegenic qualities of whatever is responsible for KD draws in many of the autoimmune disorders within rheumatology.  I hope to offer a theoretical model that could explain some of this and to back it up with enough formal experimental references to warrant a closer look. 
I offer no original work other than a theory and a site to tie together relationships.  The primary purpose of this site is to categorize related articles which are contained in the navigation links on the top in order to provoke further investigation into something that seems as simple as exposing one of the common animal models of KD to various pathogens and chemicals.

 To conclude:

1.  There is a genetic predisposition to grow some organsim naturally found in the body (i.e. some people are more likely to get it through genetics) to KD.

2.  I suspect this genetic predisposition allows/forces some organism, such as Candida which is normally found in the human body to proliferate as as base infection of self.

3.  We are exposed to another pathogen that makes this base infection of self respond or be decimated through quorum sensing and/or the killer-sensitive relationship and/or programmed cell death.  This would be described as a concomitant infection.

4.  The death/reaction of the base infection is KD (acute or atypical).  This reaction is a most severe type of 'Herxheimer reaction' often described as sepsis. 

5.  There is a genetic predisposition to regrow the base infection.

6.  As children, this base infection is mostly killed off, causing KD.  What is left is ticked off and left in an aggressive state.

7.  The base infection proliferates again (genetic predisposition) over a long period of time.

8.  Sequels, post-KD symptoms.